Trends Biotechnol|CRISPR/Cas 的表观基因组编辑: 进展、应用和临床应用

表观基因组动态调节基因表达，并在真核生物的整个生命周期中引导细胞分化。

近年来，以 CRISPR/cas 为基础的表观基因组编辑技术使研究人员能够对内源 DNA 和组蛋白进行特定位点编程的表观遗传修饰，并操纵原生染色质的结构。

因此，表观基因组编辑有助于揭示表观遗传标记和基因表达之间的因果关系。随着表观基因组编辑工具的不断发展，研究人员以新的方式应用它们来探索表观基因组在人类健康和疾病中的作用。

在这篇综述中，我们讨论了最近在 CRISPR/cas 基础上的表观基因组编辑技术的改进，这些技术已经进行了先进的临床研究，并探讨了这些技术如何能够得到改进，以获得更大的未来应用。

CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility
Trends in Biotechnology ( IF 14.343 ) Pub Date : 2021-05-07 , DOI: 10.1016/j.tibtech.2020.10.012
Jacob H. Goell, Isaac B. Hilton

The epigenome dynamically regulates gene expression and guides cellular differentiation throughout the lifespan of eukaryotic organisms. Recent advances in clustered regularly interspaced palindromic repeats (CRISPR)/Cas-based epigenome editing technologies have enabled researchers to site-specifically program epigenetic modifications to endogenous DNA and histones and to manipulate the architecture of native chromatin. As a result, epigenome editing has helped to uncover the causal relationships between epigenetic marks and gene expression. As epigenome editing tools have continued to develop, researchers have applied them in new ways to explore the function of the epigenome in human health and disease. In this review, we discuss the recent technical improvements in CRISPR/Cas-based epigenome editing that have advanced clinical research and examine how these technologies could be improved for greater future utility.

CRISPR/Cas-Based Epigenome Editing: Advances, Applications, and Clinical Utility10.1016/j.tibtech.2020.10.012

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